{"id":17635,"date":"2023-04-17T13:07:00","date_gmt":"2023-04-17T06:07:00","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=17635"},"modified":"2023-04-19T12:34:49","modified_gmt":"2023-04-19T05:34:49","slug":"triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/","title":{"rendered":"Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0"},"content":{"rendered":"

T\u1eeb l\u00e2u, ho\u1ea1t ch\u1ea5t Triptolide \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 \u0111\u00e1nh gi\u00e1 cao v\u1edbi t\u00e1c d\u1ee5ng ch\u00ednh ch\u1ed1ng l\u1ea1i s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c kh\u1ed1i u theo nhi\u1ec1u con \u0111\u01b0\u1eddng kh\u00e1c nhau. Tuy r\u1eb1ng c\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c nhau \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 nh\u01b0ng Triptolide v\u1eabn \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc v\u00e0 \u01b0a chu\u1ed9ng trong v\u1ea5n \u0111\u1ec1 gi\u1ea3i quy\u1ebft s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0<\/strong><\/p>\n

1. Gi\u1edbi thi\u1ec7u chung\u00a0<\/strong><\/h2>\n

C\u00e2y th\u01b0\u1eddng xu\u00e2n (Tripterygium wilfordii Hook.f.) l\u00e0 m\u1ed9t lo\u00e0i th\u1ef1c v\u1eadt c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb Trung Qu\u1ed1c. C\u00e2y th\u01b0\u1eddng xu\u00e2n c\u00f3 th\u00e2n th\u1ea3o, cao t\u1eeb 1-3m, l\u00e1 l\u1edbn, m\u1ecdc \u0111\u1ed1i x\u1ee9ng, d\u00e0i 10-20cm v\u00e0 r\u1ed9ng 6-12cm. Hoa c\u1ee7a c\u00e2y th\u01b0\u1eddng xu\u00e2n c\u00f3 m\u00e0u tr\u1eafng ho\u1eb7c v\u00e0ng nh\u1ea1t, m\u1ecdc th\u00e0nh ch\u00f9m \u1edf \u0111\u1ea7u c\u00e0nh. Qu\u1ea3 c\u1ee7a c\u00e2y th\u01b0\u1eddng xu\u00e2n l\u00e0 m\u1ed9t lo\u1ea1i qu\u1ea3 nang, m\u00e0u n\u00e2u s\u1eabm khi ch\u00edn v\u00e0 c\u00f3 nhi\u1ec1u h\u1ea1t b\u00ean trong.Trong y h\u1ecdc, c\u00e2y th\u01b0\u1eddng xu\u00e2n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau, bao g\u1ed3m b\u1ec7nh vi\u00eam kh\u1edbp, lupus ban \u0111\u1ecf, vi\u00eam gan,…<\/span><\/p>\n

\"H\u00ecnh
C\u00e2y th\u01b0\u1eddng xu\u00e2n<\/figcaption><\/figure>\n

C\u00e1c th\u00e0nh ph\u1ea7n \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb c\u00e2y th\u01b0\u1eddng xu\u00e2n g\u1ed3m \u03b2-sitosterol; stigmasterol; <\/span>Triptolide; syringaldehyde; 9\u2032-O-benzoyl-lariciresinol v\u00e0 wilfordoside A. Trong \u0111\u00f3, th\u00e0nh ph\u1ea7n ch\u00ednh Triptolide (TDL) l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t Triterpenoid \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u1edf \u0110\u00f4ng \u00c1 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n vi\u00eam mi\u1ec5n d\u1ecbch, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, hen suy\u1ec5n. Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh kh\u1ea3 n\u0103ng ch\u1ed1ng ung th\u01b0 c\u1ee7a Triptolide<\/span><\/p>\n

\"Triptolide
Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n<\/figcaption><\/figure>\n

2. C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Triptolide trong ch\u1ed1ng ung th\u01b0<\/strong><\/h2>\n

2.1 Ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng kh\u1ed1i u v\u00e0 ng\u0103n ung th\u01b0 c\u1ee7a Triptolide<\/span><\/h3>\n

Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u b\u1eb1ng ch\u1ee9ng cho th\u1ea5y Triptolide c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng \u0111\u1ed1i v\u1edbi ung th\u01b0 ph\u1ed5i, ung th\u01b0 gan, ung th\u01b0 tuy\u1ebfn t\u1ee5y v\u00e0 nhi\u1ec1u lo\u1ea1i kh\u1ed1i u kh\u00e1c. C\u1ee5 th\u1ec3, \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0 ph\u1ed5i, Triptolide gi\u1ea3m s\u1ef1 di chuy\u1ec3n, x\u00e2m l\u1ea5n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 do thay \u0111\u1ed5i c\u1ea5u h\u00ecnh RNA t\u1ebf b\u00e0o v\u00e0 t\u0103ng c\u01b0\u1eddng \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 v\u1edbi thu\u1ed1c h\u00f3a tr\u1ecb qua con \u0111\u01b0\u1eddng NRF2. \u0110\u1ed1i v\u1edbi ung th\u01b0 gan, Triptolide g\u00e2y ra qu\u00e1 tr\u00ecnh ch\u1ebft r\u1ee5ng t\u1ebf b\u00e0o c\u0169ng nh\u01b0 \u1ee9c ch\u1ebf s\u1ee9c s\u1ed1ng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 khi k\u00edch ho\u1ea1t gen \u1ee9c ch\u1ebf kh\u1ed1i u p53. U th\u1ea7n kinh \u0111\u1ec7m l\u00e0 u n\u00e3o nguy\u00ean ph\u00e1t \u00e1c t\u00ednh th\u01b0\u1eddng g\u1eb7p v\u00e0 g\u00e2y ch\u1ebft ng\u01b0\u1eddi c\u00f3 bi\u1ec3u hi\u1ec7n x\u00e2m l\u1ea5n m\u1ea1nh ti\u1ebfn tri\u1ec3n nhanh v\u00e0 d\u1ec5 t\u00e1i ph\u00e1t, Triptolide \u0111\u01b0\u1ee3c ch\u1ee9ng minh kh\u00f4ng ch\u1ec9 \u1ee9c ch\u1ebf s\u1ef1 t\u0103ng sinh c\u00e1c t\u1ebf b\u00e0o u th\u1ea7n kinh \u0111\u1ec7m v\u00e0 ng\u0103n ch\u1eb7n chu k\u1ef3 t\u1ebf b\u00e0o trong pha G2\/M m\u00e0 c\u00f2n g\u00e2y qu\u00e1 tr\u00ecnh t\u1ef1 th\u1ef1c c\u00e1c t\u1ebf b\u00e0o u th\u1ea7n kinh. Ngo\u00e0i ra, Triptolide can thi\u1ec7p v\u00e0o qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u00e9o c\u1ee7a t\u1ebf b\u00e0o v\u00e0 truy\u1ec1n t\u00edn hi\u1ec7u trong ung th\u01b0 bi\u1ec3u m\u00f4 tuy\u1ebfn t\u1ee5y. \u1ede nhi\u1ec1u b\u1ec7nh nh\u00e2n m\u1eafc c\u00e1c b\u1ec7nh ung th\u01b0 kh\u00e1c, hi\u1ec7u qu\u1ea3 c\u1ee7a Triptolide c\u0169ng \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u bao g\u1ed3m: Triptolide \u1ee9c ch\u1ebf s\u1ef1 t\u0103ng sinh, x\u00e2m l\u1ea5n, di c\u01b0 v\u00e0 th\u00e0nh m\u1ea1ch c\u1ee7a ung th\u01b0 mi\u1ec7ng v\u00e0 t\u1ebf b\u00e0o ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y th\u1ef1c qu\u1ea3n, Triptolide l\u00e0m ch\u1ebft nhi\u1ec1u t\u1ebf b\u00e0o ung th\u01b0 bu\u1ed3ng tr\u1ee9ng kh\u00e1ng Ciplastin\u00a0<\/span><\/p>\n

\"C\u01a1
C\u01a1 ch\u1ebf c\u1ee7a Triptolide trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0<\/figcaption><\/figure>\n

2.2 C\u00e1c ch\u1ee9c n\u0103ng sinh h\u1ecdc c\u1ee7a Triptolide<\/span><\/h3>\n

Triptolide \u1ee9c ch\u1ebf t\u1ebf b\u00e0o T ti\u1ebft c\u00e1c cytokine g\u00e2y vi\u00eam v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch t\u1ea1i c\u00e1c v\u1ecb tr\u00ed vi\u00eam trong vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p. Ngo\u00e0i ra, nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y Triptolide ph\u00e1t huy t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam th\u00f4ng qua \u1ee9c ch\u1ebf \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u nh\u00e2n t\u1ed1 -\u03baB (NF-\u03baB). H\u01a1n n\u1eefa, m\u1eb7c d\u00f9 c\u01a1 ch\u1ebf b\u1ec7nh sinh c\u1ee7a c\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh ph\u1ed5 bi\u1ebfn nh\u01b0 b\u1ec7nh Alzheimer v\u00e0 Parkinson v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m s\u00e1ng t\u1ecf, tuy nhi\u00ean c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c nh\u1eadn Triptolide c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh\u00a0<\/span><\/p>\n

3. \u1ee8ng d\u1ee5ng Triptolide trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0\u00a0<\/strong><\/h2>\n

3.1 C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 t\u00e1c d\u1ee5ng Triptolide tr\u00ean c\u00e1c lo\u1ea1i ung th\u01b0<\/span><\/h3>\n

T\u00ednh \u0111\u1ebfn hi\u1ec7n nay, vi\u1ec7c \u1ee9ng d\u1ee5ng Triptolide trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i. \u0110\u00e3 c\u00f3 r\u1ea5t nghi\u00ean c\u1ee9u cho hi\u1ec7u qu\u1ea3 kh\u1ea3 quan khi s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c nhau, bao g\u1ed3m ung th\u01b0 gan, ung th\u01b0 ph\u1ed5i, ung th\u01b0 bu\u1ed3ng tr\u1ee9ng v\u00e0 ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t. C\u1ee5 th\u1ec3, nghi\u00ean c\u1ee9u c\u1ee7a nh\u00f3m t\u00e1c gi\u1ea3 Dauer P th\u1ef1c hi\u1ec7n cho th\u1ea5y hi\u1ec7u qu\u1ea3 c\u1ee7a Triptolide trong vi\u1ec7c v\u00f4 hi\u1ec7u h\u00f3a c\u00e1c nguy\u00ean b\u00e0o s\u1ee3i l\u00e0m gi\u00e1n \u0111o\u1ea1n t\u00edn hi\u1ec7u trong t\u1ebf b\u00e0o ung th\u01b0 tuy\u1ebfn t\u1ee5y. Nghi\u00ean c\u1ee9u kh\u00e1c c\u1ee7a t\u00e1c gi\u1ea3 Brincks EL c\u00f9ng c\u1ed9ng kh\u1ea3o s\u00e1t ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Triptolide tr\u00ean di\u1ec7t kh\u1ed1i u ch\u1ed1ng l\u1ea1i ung th\u01b0 \u1edf bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o th\u1eadn v\u00e0 nghi\u00ean c\u1ee9u c\u1ee7a nh\u00f3m t\u00e1c gi\u1ea3 Banerjee S v\u1ec1 hi\u1ec7u qu\u1ea3 l\u00e0m gi\u1ea3m g\u00e1nh n\u1eb7ng kh\u1ed1i u trong b\u1ec7nh u x\u01b0\u01a1ng.\u00a0<\/span><\/p>\n

3.2 Triptolide l\u00e0m t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c<\/span><\/h3>\n

Trong h\u00f3a tr\u1ecb, TPL t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng b\u1eb1ng c\u00e1ch l\u00e0m nh\u1ea1y c\u1ea3m m\u1ed9t s\u1ed1 d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0. TPL l\u00e0m n\u1ed5i b\u1eadt t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng kh\u1ed1i u trong t\u1ebf b\u00e0o khi k\u1ebft h\u1ee3p v\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o, bao g\u1ed3m: TPL ph\u1ed1i h\u1ee3p c\u00f9ng Cisplatin ho\u1eb7c 5-FU \u0111i\u1ec1u ch\u1ec9nh l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t t\u1ebf b\u00e0o ung th\u01b0 gan \u0111\u1ed3ng th\u1eddi g\u00e2y ra m\u1ee9c \u0111\u1ed9 ch\u1ebft theo ch\u01b0\u01a1ng tr\u00ecnh cao h\u01a1n ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u01a1n l\u1ebb, TPL l\u00e0m cho c\u00e1c t\u1ebf b\u00e0o nh\u1ea1y c\u1ea3m v\u1edbi ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Carboplatin gi\u00fap ng\u1eebng ph\u00e1t tri\u1ec3n v\u00e0 l\u00e0m nh\u1eb9 tr\u1ecdng l\u01b0\u1ee3ng kh\u1ed1i u trong c\u01a1 th\u1ec3, TPL s\u1eed d\u1ee5ng chung v\u1edbi Sorafenib v\u01b0\u1ee3t tr\u1ed9i h\u01a1n \u0111i\u1ec1u tr\u1ecb \u0111\u01a1n l\u1ebb khi gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a NF-\u03baB d\u1eabn \u0111\u1ebfn l\u00e0m t\u0103ng t\u1ec9 l\u1ec7 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u, TPL khi k\u1ebft h\u1ee3p v\u1edbi Oxaliplatin (OXA) \u1ee9c ch\u1ebf hi\u1ec7u qu\u1ea3 t\u0103ng sinh trong d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 ru\u1ed9t k\u1ebft, TPL d\u00f9ng c\u00f9ng l\u00fac v\u1edbi Temozolomide (TMZ) t\u0103ng ho\u1ea1t \u0111\u1ed9ng phi\u00ean m\u00e3 NF-\u03baB v\u00e0 t\u0103ng t\u1ec9 l\u1ec7 ph\u1ea7n tr\u0103m t\u1ebf b\u00e0o ch\u1ebft trong qu\u00e1 tr\u00ecnh kh\u1edfi t\u1ea1o u th\u1ea7n kinh \u0111\u1ec7m<\/span><\/p>\n

Trong x\u1ea1 tr\u1ecb, TPL c\u1ea3i thi\u1ec7n \u0111\u1ed9 nh\u1ea1y c\u1ea3m v\u1edbi b\u1ee9c x\u1ea1 trong t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0. TPL k\u1ebft h\u1ee3p v\u1edbi b\u1ee9c x\u1ea1 c\u00f3 t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng kh\u1ed1i u \u0111\u1ed1i v\u1edbi s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a protein XIAP v\u00e0 Mcl-1\u00a0 trong t\u1ebf b\u00e0o ung th\u01b0 mi\u1ec7ng. K\u00edch th\u01b0\u1edbc v\u00e0 th\u1ebf t\u00edch kh\u1ed1i u c\u1ee7a nh\u00f3m \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng t\u00e1c nh\u00e2n k\u1ebft h\u1ee3p gi\u1ea3m \u0111\u00e1ng k\u1ec3 so v\u1edbi \u0111i\u1ec1u tr\u1ecb \u0111\u01a1n l\u1ebb<\/span><\/p>\n

4. Nh\u1eefng th\u00e1ch th\u1ee9c v\u00e0 tri\u1ec3n v\u1ecdng trong vi\u1ec7c s\u1eed d\u1ee5ng Triptolide<\/strong><\/h2>\n

4.1 H\u1ea1n ch\u1ebf\u00a0<\/span><\/h3>\n

\u0110\u1ed9c t\u00ednh: M\u1eb7c d\u00f9 TPL c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng ung th\u01b0, tuy nhi\u00ean n\u00f3 c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y \u0111\u1ed9c t\u00ednh \u0111\u1ebfn c\u00e1c t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh. TPL c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 \u0111au \u0111\u1ea7u, bu\u1ed3n n\u00f4n, m\u1ec7t m\u1ecfi, \u0111au b\u1ee5ng v\u00e0 gi\u1ea3m s\u1ee9c \u0111\u1ec1 kh\u00e1ng<\/span><\/p>\n

Kh\u1ea3 n\u0103ng th\u1ea5m qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o: TPL c\u00f3 kh\u1ea3 n\u0103ng th\u1ea5m qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o v\u00e0 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 v\u1ec1 h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng.<\/span><\/p>\n

T\u00e1c \u0111\u1ed9ng \u0111\u1ebfn h\u1ec7 mi\u1ec5n d\u1ecbch: TPL c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf h\u1ec7 mi\u1ec5n d\u1ecbch, g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 suy nh\u01b0\u1ee3c v\u00e0 nhi\u1ec5m tr\u00f9ng.\u00a0<\/span><\/p>\n

Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb d\u00e0i: V\u00ec TPL c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0, \u0111i\u1ec1u tr\u1ecb s\u1eed d\u1ee5ng TPL th\u01b0\u1eddng k\u00e9o d\u00e0i trong th\u1eddi gian d\u00e0i, g\u00e2y ra nh\u1eefng kh\u00f3 kh\u0103n cho b\u1ec7nh nh\u00e2n v\u00e0 gia \u0111\u00ecnh v\u1ec1 nhi\u1ec1u m\u1eb7t<\/span><\/p>\n

Kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c v\u1edbi thu\u1ed1c kh\u00e1c: TPL c\u00f3 kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c v\u1edbi m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c kh\u00e1c, g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c<\/span><\/p>\n

Ch\u00ednh v\u00ec v\u1eady, vi\u1ec7c s\u1eed d\u1ee5ng triptolide c\u1ea7n ph\u1ea3i \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd v\u00e0 theo d\u00f5i k\u1ef9 l\u01b0\u1ee1ng<\/span><\/p>\n

4.2 Tri\u1ec3n v\u1ecdng\u00a0<\/span><\/h3>\n

Nh\u1eefng nghi\u00ean c\u1ee9u m\u1edbi \u0111ang t\u1eadp trung vi\u1ec7c ph\u00e1t tri\u1ec3n c\u00e1c d\u1ea1ng thu\u1ed1c m\u1edbi c\u1ee7a TPL \u0111\u1ec3 c\u1ea3i thi\u1ec7n t\u00ednh h\u00f2a tan, t\u00ednh \u1ed5n \u0111\u1ecbnh v\u00e0 gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5.Khi k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c: TPL \u0111\u01b0\u1ee3c k\u1ef3 v\u1ecdng k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng, t\u1eadp th\u1ec3 d\u1ee5c v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p y h\u1ecdc b\u1ed5 tr\u1ee3 \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng t\u00ednh hi\u1ec7u qu\u1ea3 c\u1ee7a \u0111i\u1ec1u tr\u1ecb trong h\u00f3a tr\u1ecb, \u0111i\u1ec1u tr\u1ecb c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00f3 ch\u1eefa v\u00e0 m\u1ed9t s\u1ed1 b\u1ec7nh l\u00fd kh\u00e1c<\/span><\/p>\n

Ngu\u1ed3n: T\u1ed5ng h\u1ee3p<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u1eeb l\u00e2u, ho\u1ea1t ch\u1ea5t Triptolide \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 \u0111\u00e1nh gi\u00e1 cao v\u1edbi t\u00e1c d\u1ee5ng ch\u00ednh ch\u1ed1ng l\u1ea1i s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c kh\u1ed1i u theo nhi\u1ec1u con \u0111\u01b0\u1eddng kh\u00e1c nhau. Tuy r\u1eb1ng c\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c nhau \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 nh\u01b0ng Triptolide v\u1eabn \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc v\u00e0 \u01b0a chu\u1ed9ng […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,32],"tags":[3],"yoast_head":"\nTriptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0<\/title>\n<meta name=\"description\" content=\"Triptolide l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng ung th\u01b0 v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong nhi\u1ec1u n\u0103m \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u1edbi nhi\u1ec1u c\u01a1 ch\u1ebf kh\u00e1c nhau\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0\" \/>\n<meta property=\"og:description\" content=\"Triptolide l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng ung th\u01b0 v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong nhi\u1ec1u n\u0103m \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u1edbi nhi\u1ec1u c\u01a1 ch\u1ebf kh\u00e1c nhau\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-17T06:07:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-19T05:34:49+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Capture-8-300x198.png\" \/>\n<meta name=\"author\" content=\"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/\",\"name\":\"Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0\",\"isPartOf\":{\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#website\"},\"datePublished\":\"2023-04-17T06:07:00+00:00\",\"dateModified\":\"2023-04-19T05:34:49+00:00\",\"author\":{\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/55407b7fd81e248fc677fffab3aac771\"},\"description\":\"Triptolide l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng ung th\u01b0 v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong nhi\u1ec1u n\u0103m \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u1edbi nhi\u1ec1u c\u01a1 ch\u1ebf kh\u00e1c nhau\",\"breadcrumb\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/noithathoaphat.in\/ctv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#website\",\"url\":\"https:\/\/noithathoaphat.in\/ctv\/\",\"name\":\"Vinmec\",\"description\":\"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/55407b7fd81e248fc677fffab3aac771\",\"name\":\"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/2.gravatar.com\/avatar\/2cb6fe9c8b954a7fbd43938a66c2c4b9?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/2.gravatar.com\/avatar\/2cb6fe9c8b954a7fbd43938a66c2c4b9?s=96&d=mm&r=g\",\"caption\":\"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi\"},\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/nguyenngocthoainhigmail-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0","description":"Triptolide l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng ung th\u01b0 v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong nhi\u1ec1u n\u0103m \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u1edbi nhi\u1ec1u c\u01a1 ch\u1ebf kh\u00e1c nhau","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0","og_description":"Triptolide l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng ung th\u01b0 v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong nhi\u1ec1u n\u0103m \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u1edbi nhi\u1ec1u c\u01a1 ch\u1ebf kh\u00e1c nhau","og_url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/","og_site_name":"Vinmec","article_published_time":"2023-04-17T06:07:00+00:00","article_modified_time":"2023-04-19T05:34:49+00:00","og_image":[{"url":"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Capture-8-300x198.png"}],"author":"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/","url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/","name":"Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0","isPartOf":{"@id":"https:\/\/noithathoaphat.in\/ctv\/#website"},"datePublished":"2023-04-17T06:07:00+00:00","dateModified":"2023-04-19T05:34:49+00:00","author":{"@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/55407b7fd81e248fc677fffab3aac771"},"description":"Triptolide l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng ung th\u01b0 v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong nhi\u1ec1u n\u0103m \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u1edbi nhi\u1ec1u c\u01a1 ch\u1ebf kh\u00e1c nhau","breadcrumb":{"@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/triptolide-trong-cay-thuong-xuan-va-tac-dung-chong-ung-thu\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/noithathoaphat.in\/ctv\/"},{"@type":"ListItem","position":2,"name":"Triptolide trong c\u00e2y th\u01b0\u1eddng xu\u00e2n v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0"}]},{"@type":"WebSite","@id":"https:\/\/noithathoaphat.in\/ctv\/#website","url":"https:\/\/noithathoaphat.in\/ctv\/","name":"Vinmec","description":"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/55407b7fd81e248fc677fffab3aac771","name":"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/","url":"http:\/\/2.gravatar.com\/avatar\/2cb6fe9c8b954a7fbd43938a66c2c4b9?s=96&d=mm&r=g","contentUrl":"http:\/\/2.gravatar.com\/avatar\/2cb6fe9c8b954a7fbd43938a66c2c4b9?s=96&d=mm&r=g","caption":"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi"},"url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/nguyenngocthoainhigmail-com\/"}]}},"_links":{"self":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/17635"}],"collection":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/comments?post=17635"}],"version-history":[{"count":15,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/17635\/revisions"}],"predecessor-version":[{"id":24327,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/17635\/revisions\/24327"}],"wp:attachment":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media?parent=17635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/categories?post=17635"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/tags?post=17635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}