{"id":123,"date":"2023-04-13T20:58:23","date_gmt":"2023-04-13T13:58:23","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=123"},"modified":"2023-04-17T16:23:06","modified_gmt":"2023-04-17T09:23:06","slug":"thuoc-alkyl-hoa-tac-dung-phu-va-cach-xu-li","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/13\/thuoc-alkyl-hoa-tac-dung-phu-va-cach-xu-li\/","title":{"rendered":"Thu\u1ed1c Alkyl H\u00f3a trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0- T\u00e1c D\u1ee5ng Ph\u1ee5 v\u00e0 C\u00e1ch X\u1eed L\u00fd"},"content":{"rendered":"\r\n

C\u00e1c thu\u1ed1c alkyl h\u00f3a l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u01b0\u01a1ng \u0111\u1ed1i r\u1ed9ng r\u00e3i trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0, \u0111\u1eb7c bi\u1ec7t l\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 m\u00e1u, u lympho v\u00e0 c\u00e1c u \u0111\u1eb7c kh\u00e1c. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c n\u00e0y th\u01b0\u1eddng g\u00e2y kh\u00f4ng \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 l\u00ean ng\u01b0\u1eddi b\u1ec7nh nh\u01b0 n\u00f4n m\u1eeda, r\u1ee5ng t\u00f3c, suy nh\u01b0\u1ee3c c\u01a1 th\u1ec3, g\u00e2y ra nhi\u1ec1u phi\u1ec1n to\u00e1i v\u00e0 \u1ea3nh h\u01b0\u1edfng l\u1edbn t\u1edbi ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng. V\u1eady c\u01a1 ch\u1ebf g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a nh\u00f3m thu\u1ed1c n\u00e0y l\u00e0 g\u00ec v\u00e0 l\u00e0m g\u00ec \u0111\u1ec3 h\u1ea1n ch\u1ebf c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111\u00f3, b\u00e0i vi\u1ebft n\u00e0y s\u1ebd gi\u00fap b\u1ea1n gi\u1ea3i \u0111\u00e1p nh\u1eefng c\u00e2u h\u1ecfi tr\u00ean.<\/p>\r\n

1. C\u00e1c thu\u1ed1c alkyl h\u00f3a l\u00e0 g\u00ec v\u00e0 th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb lo\u1ea1i ung th\u01b0 n\u00e0o?\u00a0<\/strong><\/h2>\r\n

C\u00e1c thu\u1ed1c alkyl h\u00f3a l\u00e0 nh\u00f3m thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 b\u1eb1ng c\u00e1ch t\u1ea5n c\u00f4ng v\u00e0 ph\u00e1 h\u1ee7y c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. C\u00e1c nh\u00f3m thu\u1ed1c alkyl h\u00f3a th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng bao g\u1ed3m:
\u2022 Nitrogen mustards: Bao g\u1ed3m c\u00e1c thu\u1ed1c nh\u01b0 cyclophosphamide<\/a>, ifosfamide, chlorambucil v\u00e0 melphalan.
\u2022 Nitrosoureas: Bao g\u1ed3m c\u00e1c thu\u1ed1c nh\u01b0 carmustine<\/a>, lomustine v\u00e0 semustine.
\u2022 Methylating agents: Bao g\u1ed3m c\u00e1c thu\u1ed1c nh\u01b0 temozolomide<\/a>, dacarbazine, procarbazine v\u00e0 streptozocin.
\u2022 Alkyl sulfonates: Bao g\u1ed3m c\u00e1c thu\u1ed1c nh\u01b0 busulfan.
\u2022 Ethyleneimines: Bao g\u1ed3m c\u00e1c thu\u1ed1c nh\u01b0 thiotepa.
\u2022 Triazines: Bao g\u1ed3m c\u00e1c thu\u1ed1c nh\u01b0 dacarbazine.
C\u00e1c thu\u1ed1c alkyl h\u00f3a \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb trong m\u1ed9t s\u1ed1 lo\u1ea1i leukemia, u lympho, ung th\u01b0 v\u00fa, ung th\u01b0 bu\u1ed3ng tr\u1ee9ng, ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t v\u00e0 nhi\u1ec1u lo\u1ea1i ung th\u01b0 kh\u00e1c. Trong \u0111\u00f3, thu\u1ed1c Cyclophosphomide \u0111\u01b0\u1ee3c xem l\u00e0 nh\u00f3m c\u00f3 t\u00e1c d\u1ee5ng r\u1ed9ng v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn, ch\u1ee7 y\u1ebfu c\u00f3 t\u00e1c d\u1ee5ng trong c\u00e1c b\u1ec7nh li\u00ean quan t\u1edbi mi\u1ec5n d\u1ecbch ho\u1eb7c s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n gh\u00e9p t\u1ea1ng.<\/p>\r\n


2. C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c thu\u1ed1c alkyl h\u00f3a<\/strong><\/h2>\r\n

C\u00e1c thu\u1ed1c alkyl h\u00f3a l\u00e0 nh\u00f3m thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 b\u1eb1ng c\u00e1ch t\u1ea5n c\u00f4ng v\u00e0 ph\u00e1 h\u1ee7y c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. C\u00e1c thu\u1ed1c n\u00e0y ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch g\u1eafn v\u00e0o g\u1ed1c base c\u1ee7a c\u00e1c nucleotide trong chu\u1ed7i DNA, t\u1eeb \u0111\u00f3 g\u00e2y ra c\u00e1c \u0111\u1ed9t bi\u1ebfn gen v\u00e0 ph\u00e1 h\u1ee7y t\u1ebf b\u00e0o. C\u00e1c thu\u1ed1c alkyl h\u00f3a c\u0169ng c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n kh\u1ea3 n\u0103ng t\u00e1i s\u1ea3n xu\u1ea5t c\u1ee7a t\u1ebf b\u00e0o, t\u1eeb \u0111\u00f3 h\u1ea1n ch\u1ebf s\u1ef1 quay l\u1ea1i c\u1ee7a c\u00e1c t\u1ebf b\u00e0o \u00e1c t\u00ednh. Ho\u1ea1t t\u00ednh n\u00e0y c\u1ee7a thu\u1ed1c t\u00e1c d\u1ee5ng t\u1edbi h\u1ea7u h\u1ebft c\u00e1c pha c\u1ee7a chu k\u00ec t\u1ebf b\u00e0o. Tuy nhi\u00ean v\u00ec thu\u1ed1c t\u00e1c \u0111\u1ed9ng m\u1ea1nh nh\u1ea5t t\u1edbi c\u00e1c t\u1ebf b\u00e0o \u0111ang ph\u00e2n chia nhanh, ch\u00fang c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u1edbn nh\u1ea5t t\u1edbi c\u00e1c t\u1ebf b\u00e0o \u00e1c t\u00ednh v\u1ed1n c\u00f3 \u0111\u1eb7c t\u00ednh ph\u00e2n chia kh\u00f4ng ki\u1ec3m so\u00e1t m\u00e0 \u00edt \u1ea3nh h\u01b0\u1edfng t\u1edbi c\u00e1c t\u1ebf b\u00e0o kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3 h\u01a1n.<\/p>\r\n

(C\u00e1c thu\u1ed1c alkyl h\u00f3a l\u00e0 nh\u00f3m thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 b\u1eb1ng c\u00e1ch t\u1ea5n c\u00f4ng v\u00e0 ph\u00e1 h\u1ee7y c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. Nh\u00f3m thu\u1ed1c n\u00e0y ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch g\u1eafn v\u00e0o g\u1ed1c base c\u1ee7a c\u00e1c nucleotide trong chu\u1ed7i DNA, t\u1eeb \u0111\u00f3 g\u00e2y ra c\u00e1c \u0111\u1ed9t bi\u1ebfn gen v\u00e0 ph\u00e1 h\u1ee7y t\u1ebf b\u00e0o. \u0110\u1ed3ng th\u1eddi, ch\u00fang c\u0169ng c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n kh\u1ea3 n\u0103ng t\u00e1i s\u1ea3n xu\u1ea5t c\u1ee7a t\u1ebf b\u00e0o, t\u1eeb \u0111\u00f3 h\u1ea1n ch\u1ebf s\u1ef1 quay l\u1ea1i c\u1ee7a c\u00e1c t\u1ebf b\u00e0o \u00e1c t\u00ednh)<\/p>\r\n

\"Thu\u1ed1c<\/p>\r\n

\u00a0<\/h2>\r\n

3. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p c\u1ee7a c\u00e1c thu\u1ed1c alkyl h\u00f3a<\/strong><\/h2>\r\n

Do c\u00f3 t\u00e1c \u0111\u1ed9ng l\u00ean c\u1ea3 c\u00e1c t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh m\u1eb7c d\u00f9 v\u1edbi m\u1ee9c \u0111\u1ed9 \u00edt h\u01a1n, c\u00e1c thu\u1ed1c alkyl h\u00f3a th\u01b0\u1eddng g\u00e2y ra c\u00e1c m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng l\u1edbn t\u1edbi s\u1ee9c kh\u1ecfe v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n. T\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1eb7c tr\u01b0ng cho vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c alkyl h\u00f3a l\u00e0 s\u1ef1 \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng t\u1ee7y x\u01b0\u01a1ng. Ngo\u00e0i ra, \u1ea3nh h\u01b0\u1edfng t\u1edbi c\u00e1c t\u1ebf b\u00e0o ni\u00eam m\u1ea1c ru\u1ed9t ph\u00e2n chia nhanh c\u0169ng \u0111\u01b0\u1ee3c ghi nh\u1eadn. \u0110i\u1ec1u n\u00e0y gi\u1ea3i th\u00edch ph\u1ea7n l\u1edbn c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p c\u1ee7a thu\u1ed1c alkyl h\u00f3a, bao g\u1ed3m:
\u2022 \u1ee8c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng t\u1ee7y x\u01b0\u01a1ng:<\/strong> C\u00e1c thu\u1ed1c alkyl h\u00f3a c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng t\u1edbi c\u00e1c t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ea7u d\u00f2ng (progenitor stem cells), t\u1eeb \u0111\u00f3 \u1ea3nh h\u01b0\u1edfng t\u1edbi h\u1ea7u h\u1ebft c\u00e1c d\u00f2ng t\u1ebf b\u00e0o m\u00e1u nh\u01b0 h\u1ed3ng c\u1ea7u, b\u1ea1ch c\u1ea7u, ti\u1ec3u c\u1ea7u. T\u00e1c \u0111\u1ed9ng l\u00ean b\u1ea1ch c\u1ea7u v\u00e0 ti\u1ec3u c\u1ea7u th\u01b0\u1eddng g\u1eb7p t\u1eeb 3-4 tu\u1ea7n sau khi b\u1eaft \u0111\u1ea7u s\u1eed d\u1ee5ng thu\u1ed1c v\u00e0 k\u00e9o d\u00e0i t\u1eeb 2-3 tu\u1ea7n.
\u2022 Suy gi\u1ea3m mi\u1ec5n d\u1ecbch:<\/strong> Thu\u1ed1c alkyl h\u00f3a c\u00f3 th\u1ec3 l\u00e0m suy gi\u1ea3m mi\u1ec5n d\u1ecbch do \u1ee9c ch\u1ebf s\u1ef1 sinh s\u1ea3n v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u1eeb t\u1ee7y x\u01b0\u01a1ng (TB lympho B, lympho T, b\u1ea1ch c\u1ea7u \u0111a nh\u00e2n trung t\u00ednh, v,v.), t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng. Hi\u1ec7u \u1ee9ng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch th\u01b0\u1eddng l\u1edbn nh\u1ea5t \u1edf nh\u00f3m Cyclophosphamide.
\u2022 T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean h\u1ec7 ti\u00eau h\u00f3a:<\/strong> Thu\u1ed1c alkyl h\u00f3a c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean h\u1ec7 ti\u00eau h\u00f3a, bao g\u1ed3m \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y v\u00e0 t\u00e1o b\u00f3n.
\u2022 Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n m\u1eeda:<\/strong> Thu\u1ed1c alkyl h\u00f3a c\u00f3 th\u1ec3 g\u00e2y ra bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n m\u1eeda, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong nh\u1eefng gi\u1edd \u0111\u1ea7u sau khi ti\u00eam thu\u1ed1c. Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y th\u01b0\u1eddng t\u1ec9 l\u1ec7 thu\u1eadn v\u1edbi li\u1ec1u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng n\u00f4n truy\u1ec1n th\u1ed1ng th\u01b0\u1eddng \u00edt c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean nh\u00f3m thu\u1ed1c n\u00e0y.
\u2022 R\u1ee5ng t\u00f3c:<\/strong> Thu\u1ed1c alkyl h\u00f3a c\u00f3 th\u1ec3 g\u00e2y ra r\u1ee5ng t\u00f3c t\u01b0\u01a1ng \u0111\u1ed1i nghi\u00eam tr\u1ecdng. T\u00f3c m\u1ecdc l\u1ea1i sau khi s\u1eed d\u1ee5ng thu\u1ed1c c\u00f3 th\u1ec3 c\u00f3 s\u1ef1 thay \u0111\u1ed5i v\u1ec1 m\u00e0u s\u1eafc v\u00e0 tr\u1edf n\u00ean xo\u0103n h\u01a1n.<\/p>\r\n

\"H\u00ecnh
\u2022 T\u00e1c \u0111\u1ed9ng l\u00ean th\u1eadn v\u00e0 b\u00e0ng quang:<\/strong> Vi\u00eam b\u00e0ng quang ch\u1ea3y m\u00e1u l\u00e0 m\u1ed9t t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1eb7c tr\u01b0ng cho thu\u1ed1c Cyclophosphamide v\u00e0 Ifosfamide, x\u1ea3y ra do s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a s\u1ea3n ph\u1ea9m chuy\u1ec3n h\u00f3a acrolein trong n\u01b0\u1edbc ti\u1ec3u. B\u00ean c\u1ea1nh \u0111\u00f3, khi s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c thu\u1ed9c nh\u00f3m Nitrosoureas, t\u1ed5n th\u01b0\u01a1ng th\u1eadn ph\u1ee5 thu\u1ed9c li\u1ec1u c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n, th\u1eadm ch\u00ed d\u1eabn t\u1edbi suy th\u1eadn v\u00e0 t\u1eed vong.
\u2022 T\u00e1c \u0111\u1ed9ng l\u00ean ph\u1ed5i:<\/strong> Vi\u00eam ph\u1ed5i k\u1ebd, vi\u00eam ph\u1ebf qu\u1ea3n, x\u01a1 ph\u1ed5i l\u00e0 m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean ph\u1ed5i c\u00f3 th\u1ec3 g\u00e2y ra b\u1edfi vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c alkyl h\u00f3a, \u0111\u1eb7c bi\u1ec7t l\u00e0 Busulfan, Cyclophosphamise v\u00e0 m\u1ed9t s\u1ed1 thu\u1ed1c thu\u1ed9c nh\u00f3m Nitrosoureas khi s\u1eed d\u1ee5ng l\u00e2u d\u00e0i v\u00e0 c\u00f3 li\u1ec1u t\u00edch l\u0169y cao.
\u2022 T\u00e1c \u0111\u1ed9ng l\u00ean kh\u1ea3 n\u0103ng sinh s\u1ea3n:<\/strong> \u1ede nam, hi\u1ec7n t\u01b0\u1ee3ng suy gi\u1ea3m tinh tr\u00f9ng ho\u1eb7c v\u00f4 tinh c\u00f3 th\u1ec3 x\u1ea3y ra trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c trong khi v\u00f4 kinh v\u00e0 teo bu\u1ed3ng tr\u1ee9ng c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf n\u1eef. C\u00e1c t\u1ed5n th\u01b0\u01a1ng n\u00e0y nh\u00ecn chung l\u00e0 c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c, tr\u1eeb m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p nh\u01b0 ph\u1ee5 n\u1eef l\u1edbn tu\u1ed5i v\u00e0 ti\u1ec1n m\u00e3n kinh.
\u2022 Ph\u00e1t tri\u1ec3n c\u00e1c d\u1ea1ng ung th\u01b0 kh\u00e1c:<\/strong> Vi\u1ec7c b\u1ec7nh nh\u00e2n ph\u00e1t tri\u1ec3n th\u00eam m\u1ed9t d\u1ea1ng ung th\u01b0 th\u1ee9 c\u1ea5p khi s\u1eed d\u1ee5ng thu\u1ed1c alkyl h\u00f3a \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o.
\u2022 T\u00e1c \u0111\u1ed9ng l\u00ean h\u1ec7 th\u1ea7n kinh:<\/strong> H\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 ngo\u1ea1i vi c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng khi s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c alkyl h\u00f3a li\u1ec1u cao, g\u00e2y ra \u0111au \u0111\u1ea7u, cho\u00e1ng v\u00e1ng, co gi\u1eadt, thay \u0111\u1ed5i tr\u1ea1ng th\u00e1i nh\u1eadn th\u1ee9c, h\u00f4n m\u00ea.<\/p>\r\n


4. C\u00e1ch h\u1ea1n ch\u1ebf t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n khi s\u1eed d\u1ee5ng thu\u1ed1c alkyl h\u00f3a<\/strong><\/h2>\r\n

\u2022 U\u1ed1ng nhi\u1ec1u n\u01b0\u1edbc v\u00e0 \u0111i ti\u1ec3u th\u01b0\u1eddng xuy\u00ean: Vi\u1ec7c u\u1ed1ng nhi\u1ec1u n\u01b0\u1edbc v\u00e0 \u0111i ti\u1ec3u th\u01b0\u1eddng xuy\u00ean c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 l\u1ecdc v\u00e0 th\u1ea3i c\u00e1c ch\u1ea5t \u0111\u1ed9c chuy\u1ec3n h\u00f3a, t\u1eeb \u0111\u00f3 h\u1ea1n ch\u1ebf t\u00e1c d\u1ee5ng ph\u1ee5 l\u00ean th\u1eadn. Thu\u1ed1c MESNA c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00ea \u0111\u1ec3 h\u1ed7 tr\u1ee3 k\u00edch th\u00edch b\u00e0ng quang, t\u1eeb \u0111\u00f3 b\u1ea3o v\u1ec7 th\u1eadn v\u00e0 b\u00e0ng quang.
\u2022 S\u1eed d\u1ee5ng garo ho\u1eb7c \u0111\u00e1 ch\u01b0\u1eddm l\u00ean da \u0111\u1ea7u trong v\u00e0 sau khi truy\u1ec1n Cyclophosphamide c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c \u0111\u1ed9ng g\u00e2y r\u1ee5ng t\u00f3c.
\u2022 T\u00edch c\u1ef1c b\u1ea3o v\u1ec7 b\u1ea3n th\u00e2n kh\u1ecfi nhi\u1ec5m tr\u00f9ng \u0111\u1ec3 tr\u00e1nh h\u1eadu qu\u1ea3 do suy gi\u1ea3m mi\u1ec5n d\u1ecbch. M\u1ed9t s\u1ed1 ho\u1ea1t \u0111\u1ed9ng d\u1ec5 d\u00e0ng c\u00f3 th\u1ec3 th\u01b0\u1eddng xuy\u00ean th\u1ef1c hi\u1ec7n l\u00e0 r\u1eeda tay, \u0111eo kh\u1ea9u trang t\u1ea1i n\u01a1i c\u00f4ng c\u1ed9ng, s\u1eed d\u1ee5ng c\u00e1c th\u1ef1c ph\u1ea9m t\u0103ng c\u01b0\u1eddng mi\u1ec5n d\u1ecbch.
\u0110\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 t\u1ed1i \u0111a c\u1ee7a vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c v\u00e0 h\u1ea1n ch\u1ebf t\u00e1c d\u1ee5ng ph\u1ee5, b\u1ec7nh nh\u00e2n c\u1ea7n theo s\u00e1t ch\u1ec9 \u0111\u1ecbnh v\u00e0 h\u01b0\u1edbng d\u1eabn c\u1ee7a y b\u00e1c s\u0129. H\u00e3y th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 c\u1ee7a m\u00ecnh ngay khi g\u1eb7p ph\u1ea3i nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 k\u1ec3 tr\u00ean ho\u1eb7c c\u00f3 b\u1ea5t k\u00ec b\u1ea5t th\u01b0\u1eddng n\u00e0o trong qu\u00e1 tr\u00ecnh d\u00f9ng thu\u1ed1c c\u0169ng nh\u01b0 th\u1ef1c hi\u1ec7n c\u00e1c x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng \u0111\u1ec3 theo d\u00f5i \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c l\u00ean c\u01a1 th\u1ec3.<\/p>\r\n","protected":false},"excerpt":{"rendered":"

C\u00e1c thu\u1ed1c alkyl h\u00f3a l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u01b0\u01a1ng \u0111\u1ed1i r\u1ed9ng r\u00e3i trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0, \u0111\u1eb7c bi\u1ec7t l\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 m\u00e1u, u lympho v\u00e0 c\u00e1c u \u0111\u1eb7c kh\u00e1c. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c n\u00e0y th\u01b0\u1eddng g\u00e2y kh\u00f4ng \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 l\u00ean ng\u01b0\u1eddi b\u1ec7nh nh\u01b0 n\u00f4n […]<\/p>\n","protected":false},"author":47,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,33],"tags":[3],"yoast_head":"\nThu\u1ed1c Alkyl H\u00f3a trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0- T\u00e1c D\u1ee5ng Ph\u1ee5 v\u00e0 C\u00e1ch X\u1eed L\u00fd<\/title>\n<meta name=\"description\" content=\"S\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c alkyl h\u00f3a trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 th\u01b0\u1eddng g\u00e2y nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 phi\u1ec1n to\u00e1i v\u00e0 \u1ea3nh h\u01b0\u1edfng t\u1edbi ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng ng\u01b0\u1eddi b\u1ec7nh\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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