{"id":1160,"date":"2023-04-08T20:23:42","date_gmt":"2023-04-08T13:23:42","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=1160"},"modified":"2023-04-13T13:01:29","modified_gmt":"2023-04-13T06:01:29","slug":"p53-nguoi-bao-ve-cua-bo-gen","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/","title":{"rendered":"p53-“Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen” v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0"},"content":{"rendered":"

P53 l\u00e0 m\u1ed9t protein c\u00f3 vai tr\u00f2 ki\u1ec3m so\u00e1t s\u1ef1 ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa ADN, protein n\u00e0y \u0111\u01b0\u1ee3c m\u00e3 h\u00f3a t\u1eeb gen \u1ee9c ch\u1ebf kh\u1ed1i u p53. Do \u0111\u00f3, p53 c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 “Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 b\u1ed9 gen” c\u1ee7a t\u1ebf b\u00e0o. B\u00e0i vi\u1ebft s\u1ebd cung c\u1ea5p nh\u1eefng th\u00f4ng tin c\u01a1 b\u1ea3n v\u1ec1 c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a p53 c\u0169ng nh\u01b0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 do \u0111\u1ed9t bi\u1ebfn gen p53 ph\u1ed5 bi\u1ebfn tr\u00ean l\u00e2m s\u00e0ng.<\/strong><\/p>\n

1. C\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a p53<\/h4>\n

\"Thu\u1ed1c<\/p>\n

P53 l\u00e0 m\u1ed9t protein c\u00f3 k\u00edch th\u01b0\u1edbc kho\u1ea3ng 53 kilodalton v\u00e0 \u0111\u01b0\u1ee3c m\u00e3 h\u00f3a b\u1edfi gen TP53.<\/p>\n

C\u1ea5u tr\u00fac c\u1ee7a P53 bao g\u1ed3m nhi\u1ec1u mi\u1ebfng c\u1ea5u tr\u00fac nh\u01b0 mi\u1ebfng beta-sheet, mi\u1ebfng alpha-helix v\u00e0 mi\u1ebfng loop. P53 c\u00f3 ba mi\u1ebfng kh\u00e1c nhau g\u1ecdi l\u00e0 domain N-terminal, domain DNA-binding v\u00e0 domain C-terminal. Domain N-terminal ch\u1ecbu tr\u00e1ch nhi\u1ec7m k\u00edch ho\u1ea1t c\u00e1c gen li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA, domain DNA-binding li\u00ean k\u1ebft v\u1edbi c\u00e1c v\u00f9ng \u0111\u1eb7c bi\u1ec7t c\u1ee7a DNA v\u00e0 domain C-terminal ch\u1ee9a c\u00e1c mi\u1ebfng c\u1ea5u tr\u00fac nh\u01b0 mi\u1ebfng alpha-helix v\u00e0 mi\u1ebfng loop.<\/p>\n

Protein p53 c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u ti\u1ebft s\u1ef1 s\u1ed1ng c\u00f2n c\u1ee7a t\u1ebf b\u00e0o, bao g\u1ed3m vi\u1ec7c ki\u1ec3m so\u00e1t qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh (apoptosis). Khi t\u1ebf b\u00e0o b\u1ecb t\u1ed5n th\u01b0\u01a1ng ho\u1eb7c g\u1eb7p ph\u1ea3i stress, p53 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t v\u00e0 b\u1eaft \u0111\u1ea7u k\u00edch ho\u1ea1t c\u00e1c con \u0111\u01b0\u1eddng l\u00e0m cho t\u1ebf b\u00e0o t\u1ef1 di\u1ec7t, bao g\u1ed3m apoptosis, \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0.<\/p>\n

C\u01a1 ch\u1ebf ch\u00ednh c\u1ee7a p53 trong qu\u00e1 tr\u00ecnh apoptotic l\u00e0 k\u00edch ho\u1ea1t c\u00e1c gen \u0111\u00edch li\u00ean quan \u0111\u1ebfn apoptosis. Protein p53 k\u00edch ho\u1ea1t c\u1ea3 hai \u0111\u01b0\u1eddng \u0111i ch\u00ednh d\u1eabn \u0111\u1ebfn apoptosis, bao g\u1ed3m con \u0111\u01b0\u1eddng n\u1ed9i b\u00e0o v\u00e0 con \u0111\u01b0\u1eddng ngo\u1ea1i b\u00e0o. Con \u0111\u01b0\u1eddng n\u1ed9i b\u00e0o bao g\u1ed3m k\u00edch ho\u1ea1t c\u00e1c protein pro-apoptotic nh\u01b0 BAX v\u00e0 PUMA, v\u00e0 con \u0111\u01b0\u1eddng ngo\u1ea1i b\u00e0o bao g\u1ed3m k\u00edch ho\u1ea1t Fas v\u00e0 TNF-alpha.<\/p>\n

Khi p53 k\u00edch ho\u1ea1t c\u00e1c con \u0111\u01b0\u1eddng apoptosis, c\u00e1c t\u1ebf b\u00e0o s\u1ebd b\u1eaft \u0111\u1ea7u qu\u00e1 tr\u00ecnh t\u1ef1 di\u1ec7t, gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0. Tuy nhi\u00ean, n\u1ebfu gen TP53 b\u1ecb \u0111\u1ed9t bi\u1ebfn ho\u1eb7c m\u1ea5t ch\u1ee9c n\u0103ng, s\u1ebd d\u1eabn \u0111\u1ebfn s\u1ef1 gi\u1ea3m thi\u1ec3u ho\u1eb7c m\u1ea5t kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t s\u1ef1 ph\u00e2n chia c\u1ee7a t\u1ebf b\u00e0o, g\u00e2y ra c\u00e1c b\u1ea5t th\u01b0\u1eddng trong qu\u00e1 tr\u00ecnh apoptotic v\u00e0 t\u0103ng nguy c\u01a1 h\u00ecnh th\u00e0nh ung th\u01b0.<\/p>\n

Do \u0111\u00f3, vi\u1ec7c \u0111i\u1ec1u ti\u1ebft ho\u1ea1t \u0111\u1ed9ng c\u1ee7a protein p53 trong qu\u00e1 tr\u00ecnh apoptotic l\u00e0 r\u1ea5t quan tr\u1ecdng trong vi\u1ec7c ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0 v\u00e0 c\u1ea3i thi\u1ec7n \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd ung th\u01b0. C\u00e1c nghi\u00ean c\u1ee9u \u0111ang t\u1eadp trung v\u00e0o vi\u1ec7c nghi\u00ean c\u1ee9u c\u00e1ch t\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a p53 trong qu\u00e1 tr\u00ecnh apoptotic, nh\u1eb1m ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u1edbi hi\u1ec7u qu\u1ea3 h\u01a1n.<\/p>\n

2. C\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 do \u0111\u1ed9t bi\u1ebfn gen p53<\/h4>\n

C\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 do \u0111\u1ed9t bi\u1ebfn gen p53 l\u00e0 c\u00e1c b\u1ec7nh l\u00fd li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0 do c\u00e1c \u0111\u1ed9t bi\u1ebfn trong gen TP53, d\u1eabn \u0111\u1ebfn m\u1ea5t kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t s\u1ef1 ph\u00e2n chia c\u1ee7a t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA. C\u00e1c h\u1ed9i ch\u1ee9ng n\u00e0y bao g\u1ed3m:<\/p>\n

    \n
  • Li-Fraumeni syndrome (LFS):<\/strong> LFS l\u00e0 m\u1ed9t h\u1ed9i ch\u1ee9ng ung th\u01b0 di truy\u1ec1n hi\u1ebfm g\u1eb7p, \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1edfi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a nhi\u1ec1u lo\u1ea1i ung th\u01b0 kh\u00e1c nhau trong gia \u0111\u00ecnh. C\u00e1c lo\u1ea1i ung th\u01b0 th\u01b0\u1eddng g\u1eb7p \u1edf LFS l\u00e0 ung th\u01b0 v\u00fa, ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, ung th\u01b0 n\u00e3o, ung th\u01b0 th\u1eadn v\u00e0 ung th\u01b0 x\u01b0\u01a1ng.<\/li>\n
  • Chordoma syndrome:<\/strong> Chordoma syndrome l\u00e0 m\u1ed9t h\u1ed9i ch\u1ee9ng di truy\u1ec1n hi\u1ebfm g\u1eb7p, \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t d\u1ea1ng c\u1ee7a Li-Fraumeni syndrome (LFS) do \u0111\u1ed9t bi\u1ebfn gen TP53. Chordoma syndrome \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c kh\u1ed1i u trong c\u00e1c m\u00f4 li\u00ean k\u1ebft v\u1edbi x\u01b0\u01a1ng, bao g\u1ed3m c\u1ed9t s\u1ed1ng, s\u1ecd v\u00e0 x\u01b0\u01a1ng ch\u1eadu.<\/li>\n
  • Li-Fraumeni-like syndrome (LFL):<\/strong> Li-Fraumeni-like syndrome (LFL) l\u00e0 m\u1ed9t h\u1ed9i ch\u1ee9ng di truy\u1ec1n c\u00f3 li\u00ean quan \u0111\u1ebfn Li-Fraumeni syndrome (LFS), m\u1ed9t lo\u1ea1i ung th\u01b0 di truy\u1ec1n do \u0111\u1ed9t bi\u1ebfn gen TP53. Tuy nhi\u00ean, LFL l\u00e0 m\u1ed9t d\u1ea1ng LFS nh\u1eb9 h\u01a1n, v\u1edbi c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m l\u00e2m s\u00e0ng v\u00e0 di truy\u1ec1n kh\u00f4ng r\u00f5 r\u00e0ng nh\u01b0 LFS. C\u00e1c b\u1ec7nh nh\u00e2n LFL c\u00f3 nguy c\u01a1 cao m\u1eafc c\u00e1c lo\u1ea1i ung th\u01b0, \u0111\u1eb7c bi\u1ec7t l\u00e0 ung th\u01b0 v\u00fa, ung th\u01b0 th\u1eadn v\u00e0 ung th\u01b0 n\u00e3o. Ngo\u00e0i ra, c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra, bao g\u1ed3m ung th\u01b0 gan, ung th\u01b0 ph\u1ed5i, ung th\u01b0 gan m\u1eadt v\u00e0 ung th\u01b0 tuy\u1ebfn gi\u00e1p.<\/li>\n<\/ul>\n

    T\u00f3m l\u1ea1i, c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 do \u0111\u1ed9t bi\u1ebfn gen p53 c\u00f3 xu h\u01b0\u1edbng di truy\u1ec1n theo d\u1ea1ng tr\u1ed9i tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 th\u01b0\u1eddng<\/strong>, c\u00f3 ngh\u0129a l\u00e0 ch\u1ec9 c\u1ea7n m\u1ed9t b\u1ea3n sao c\u1ee7a gen TP53 \u0111\u1ed9t bi\u1ebfn \u0111\u1ec3 g\u00e2y ra b\u1ec7nh. Nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 cao b\u1ecb m\u1eafc c\u00e1c h\u1ed9i ch\u1ee9ng n\u00e0y c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i ch\u1eb7t ch\u1ebd b\u1edfi nh\u1eefng chuy\u00ean gia y t\u1ebf \u0111\u1ec3 ph\u00e1t hi\u1ec7n s\u1edbm c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a ung th\u01b0 v\u00e0 c\u00f3 c\u00e1c bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba s\u1edbm nh\u1ea5t.<\/p>\n","protected":false},"excerpt":{"rendered":"

    P53 l\u00e0 m\u1ed9t protein c\u00f3 vai tr\u00f2 ki\u1ec3m so\u00e1t s\u1ef1 ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa ADN, protein n\u00e0y \u0111\u01b0\u1ee3c m\u00e3 h\u00f3a t\u1eeb gen \u1ee9c ch\u1ebf kh\u1ed1i u p53. Do \u0111\u00f3, p53 c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 “Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 b\u1ed9 gen” c\u1ee7a t\u1ebf b\u00e0o. B\u00e0i vi\u1ebft s\u1ebd cung c\u1ea5p nh\u1eefng th\u00f4ng tin c\u01a1 b\u1ea3n […]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[33,14],"tags":[3],"yoast_head":"\np53-"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen" v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 - Vinmec<\/title>\n<meta name=\"description\" content=\"P53 l\u00e0 m\u1ed9t protein ki\u1ec3m so\u00e1t ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA, do \u0111\u00f3 n\u00f3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 "Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 b\u1ed9 gen" c\u1ee7a t\u1ebf b\u00e0o\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"p53-"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen" v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 - Vinmec\" \/>\n<meta property=\"og:description\" content=\"P53 l\u00e0 m\u1ed9t protein ki\u1ec3m so\u00e1t ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA, do \u0111\u00f3 n\u00f3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 "Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 b\u1ed9 gen" c\u1ee7a t\u1ebf b\u00e0o\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-08T13:23:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-13T06:01:29+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/DNA-Break_2880_Lede-300x156.jpg\" \/>\n<meta name=\"author\" content=\"Phu Pham\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Phu Pham\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/\",\"name\":\"p53-\\\"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen\\\" v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 - Vinmec\",\"isPartOf\":{\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#website\"},\"datePublished\":\"2023-04-08T13:23:42+00:00\",\"dateModified\":\"2023-04-13T06:01:29+00:00\",\"author\":{\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/d1ff6c1232842b1dc8185f0a7f0391ed\"},\"description\":\"P53 l\u00e0 m\u1ed9t protein ki\u1ec3m so\u00e1t ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA, do \u0111\u00f3 n\u00f3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \\\"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 b\u1ed9 gen\\\" c\u1ee7a t\u1ebf b\u00e0o\",\"breadcrumb\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/noithathoaphat.in\/ctv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"p53-“Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen” v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#website\",\"url\":\"https:\/\/noithathoaphat.in\/ctv\/\",\"name\":\"Vinmec\",\"description\":\"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/d1ff6c1232842b1dc8185f0a7f0391ed\",\"name\":\"Phu Pham\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/2.gravatar.com\/avatar\/2e40cd35d82629134715ab35f6e3d9b6?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/2.gravatar.com\/avatar\/2e40cd35d82629134715ab35f6e3d9b6?s=96&d=mm&r=g\",\"caption\":\"Phu Pham\"},\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/phuphamctumpgmail-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"p53-\"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen\" v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 - Vinmec","description":"P53 l\u00e0 m\u1ed9t protein ki\u1ec3m so\u00e1t ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA, do \u0111\u00f3 n\u00f3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 b\u1ed9 gen\" c\u1ee7a t\u1ebf b\u00e0o","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"p53-\"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen\" v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 - Vinmec","og_description":"P53 l\u00e0 m\u1ed9t protein ki\u1ec3m so\u00e1t ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA, do \u0111\u00f3 n\u00f3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 b\u1ed9 gen\" c\u1ee7a t\u1ebf b\u00e0o","og_url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/","og_site_name":"Vinmec","article_published_time":"2023-04-08T13:23:42+00:00","article_modified_time":"2023-04-13T06:01:29+00:00","og_image":[{"url":"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/DNA-Break_2880_Lede-300x156.jpg"}],"author":"Phu Pham","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Phu Pham","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/","url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/","name":"p53-\"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen\" v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0 - Vinmec","isPartOf":{"@id":"https:\/\/noithathoaphat.in\/ctv\/#website"},"datePublished":"2023-04-08T13:23:42+00:00","dateModified":"2023-04-13T06:01:29+00:00","author":{"@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/d1ff6c1232842b1dc8185f0a7f0391ed"},"description":"P53 l\u00e0 m\u1ed9t protein ki\u1ec3m so\u00e1t ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA, do \u0111\u00f3 n\u00f3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \"Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 b\u1ed9 gen\" c\u1ee7a t\u1ebf b\u00e0o","breadcrumb":{"@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/p53-nguoi-bao-ve-cua-bo-gen\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/noithathoaphat.in\/ctv\/"},{"@type":"ListItem","position":2,"name":"p53-“Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 c\u1ee7a b\u1ed9 gen” v\u00e0 c\u00e1c h\u1ed9i ch\u1ee9ng ung th\u01b0"}]},{"@type":"WebSite","@id":"https:\/\/noithathoaphat.in\/ctv\/#website","url":"https:\/\/noithathoaphat.in\/ctv\/","name":"Vinmec","description":"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/d1ff6c1232842b1dc8185f0a7f0391ed","name":"Phu Pham","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/","url":"http:\/\/2.gravatar.com\/avatar\/2e40cd35d82629134715ab35f6e3d9b6?s=96&d=mm&r=g","contentUrl":"http:\/\/2.gravatar.com\/avatar\/2e40cd35d82629134715ab35f6e3d9b6?s=96&d=mm&r=g","caption":"Phu Pham"},"url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/phuphamctumpgmail-com\/"}]}},"_links":{"self":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/1160"}],"collection":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/comments?post=1160"}],"version-history":[{"count":8,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/1160\/revisions"}],"predecessor-version":[{"id":2221,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/1160\/revisions\/2221"}],"wp:attachment":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media?parent=1160"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/categories?post=1160"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/tags?post=1160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}